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Legal

Make sure you don't make misleading or unreasonable claims on your website, and have a disclaimer that is easy to access.

Read these recommendations from the US FTC for online businesses - DotComGuide

For scary examples, visit these sites:
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As of 1 Nov 2003, if you have a mailing list, you need to ensure you have their name, permission, and agreement to accept advertising from you, and possibly third parties.